Summary scheme of possible role of PPARγ modulation in counteracting PUVA-SIPS of HDFs.

PUVA exposure induced intracellular generation of ROS, alteration of mitochondria function, activation of antioxidant stress response and MAPK phosphorylation pathway, dysregulation of membrane lipid metabolism, DNA-oxidative damage and altered expression of cell cycle regulators. PPARγ modulation by Octa may counteract PUVA-induced senescence-like phenotype. Moreover, Octa ability to reduce phospholipid oxidation and oxysterol generation contributes to the reduction of PUVA-induced inflammatory response and redox imbalance.