Table_2.xls (5.5 kB)
Summary of the IC50 (μM) values obtained for each antagonist drug with their respective Anticholinergic Cognitive Burden (ACB) and Serum Anticholinergic Activity (SAA) scores.
dataset
posted on 2015-03-04, 03:02 authored by Elizabeth K. Woehrling, H. Rheinallt Parri, Erin H. Y. Tse, Eric J. Hill, Ian D. Maidment, G. Christopher Fox, Michael D. ColemanValues represent the mean IC50 values (μM) ± SEM (n = 3) for each drug.
Compared IC50s;
a dicycloverine vs amitriptyline,
b amitriptyline vs cyclobenzaprine and
c cyclobenzaprine vs cimetidine.
* P < 0.05,
** P < 0.01,
*** P < 0.001
Summary of the IC50 (μM) values obtained for each antagonist drug with their respective Anticholinergic Cognitive Burden (ACB) and Serum Anticholinergic Activity (SAA) scores.
History
Usage metrics
Categories
Keywords
intracellular calciumcholinergic responseamitriptylinepolypharmacyquantitate increasesmAChR agonist oxotremorineanticholinergic responsesACB scoresanticholinergic effectsVitro Modelanticholinergic riskinvestigationACB scaledicycloverinedrug usedrug scoresNT 2 astrocytescholinergic phenotypic markerscyclobenzaprineMuscarinic acetylcholine receptorsHuman NeuronalNT 2.N cellsAnticholinergic PropertiesNT 2.NNT 2 cell lineastrocytic cholinergic responsemedicationneuronAstrocytic SystemscimetidinecombinationNT 2.N modelAnticholinergic Cognitive Burden
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC