Summary of phenotypes observed for NS5A mutants and PI4KIIIα silencing.

<p>Silencing of shPI4KIIIα is given in italics.</p><p>PFIS mutants are given in bold italics.</p>1<p>according to data obtained from <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003359#ppat-1003359-g003" target="_blank">figure 3B</a>; +++: wt type or higher; ++: 10–99% wt; +: 1–9% wt; +/−: residual low level replication; −: no replication.</p>2<p>according to data obtained from <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003359#ppat-1003359-g002" target="_blank">figure 2C</a>; +++:wt or higher; ++: 50–99%wt; +: 26–49% wt; +/−: 20–25% wt; −: below 20% wt.</p>3<p>according to data obtained from <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003359#ppat-1003359-g004" target="_blank">figure 4B</a>; +++:>50%; ++: 26–50%; +: 11–25%; +/−: >5–10%; −: <5% of cells with MW clusters visible in IF.</p>4<p>according to data obtained from <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003359#ppat-1003359-g004" target="_blank">figure 4C</a>; +++:>4fold mock; ++: 3–4 fold mock; +: 2–3 fold mock; +/−: >1.5–2fold mock; −: 1–1.5fold mock.</p>5<p>according to data obtained from <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003359#ppat-1003359-g006" target="_blank">figure 6B</a>; +++: 1 or higher; ++: 0.5–0.9; +: 0.1–0.4.</p>§<p>Data not shown.</p>*<p>According to Reiss et al., CHM 2011.</p>