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Structure-activity relationship: charged ethyltrimethylamine critical for target potency.

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posted on 2014-12-01, 03:34 authored by Kareem L. Graham, Jian V. Zhang, Susanna Lewén, Thomas M. Burke, Ton Dang, Maria Zoudilova, Raymond A. Sobel, Eugene C. Butcher, Brian A. Zabel
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IC50 (µM), mean±SEM, n = 3-14 independent experiments per assay per compound.

Structure-activity relationship: charged ethyltrimethylamine critical for target potency.

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    CMKLR 1 KONovel CMKLR 1animal modelhistological EAECMKLR 1encephalitogenic T cellsdisease activitychemoattractant receptormsmolecule antagonisttarget leukocyte trafficking pathwaysDisease TherapiesCMKLR 1 KO phenotypeCMKLR 1 inhibitorshistological featureskiller cellscell infiltratesC 57BL miceMolecule Antagonist Suppresses CNS Autoimmuneeffector cellsNETADendritic cells

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