Structural topology of holo-Tth-MCO and superposition with others MCÓs.

A) Multinuclear metal site of the holo-Tth-MCO. B) Structural depiction of the three cupredoxin domains of holo-Tth-MCO, (domain 1, green), (domain 2, light blue) and (domain 3, yellow), the loop (β21–β24)_D2 is in deep blue cartoons. C) Ribbon superposition of the holo forms of Tth-MCO (green), CueO (red, PDB entry 1N68) and CotA (blue, PDB entry 1UVW), the main differences among them are represented in cartoon structure. Mononuclear copper center (T1Cu) is shown in blue and trinuclear copper cluster (TNC) is shown in orange (T3Cu) and red (T2Cu) Van der Waals representation.