Stable knockdown of BDNF activity inhibits tumor growth and prolongs overall survival in vivo.

(A) Representative fluorescence images of SCID-rab mice harboring the myeloma xenograft tumors. Mice harboring AS-ARH cells suffered lower tumor burden than animals harboring EV-ARH cells. (B) Circulating human IgG levels in SCID-rab mice were detected by ELISA. Human IgG levels began to show a difference 2 weeks after ARH inoculation, and the difference became increasingly marked. Circulating human IgG levels in the AS-ARH group was significantly lower than the EV-ARH and WT-ARH group at 6 weeks (P<0.05). (C) The effects of BDNF knockdown on overall survival were analyzed by Kaplan–Meier curves and long-rank tests.