Stability of mutated transcripts in xenografts.

The prevalence of a glutamine to stop codon mutation at the 861 amino acid position of APC (APC:Q861*) and a glutamate to lysine mutation at 51 amino acid position of TCF7L2 were evaluated on the forward and reverse transcripts from the parental human tumors (gray rows) and first and second generation xenografts (white rows) of D61540 and P2726, respectively.




CC BY 4.0