Figure_1.tif (172.38 kB)
Sphingolipid levels in the livers of DIO mice after treatment with Genz-112638.
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posted on 2013-02-21, 00:51 authored by Nelson S. Yew, Hongmei Zhao, Eun-Gyoung Hong, I-Huan Wu, Malgorzata Przybylska, Craig Siegel, James A. Shayman, Cynthia M. Arbeeny, Jason K. Kim, Canwen Jiang, Seng H. ChengC57BL/6 mice were fed a normal diet (Lean) or a HFD (DIO) for 8 weeks. The DIO mice were then treated with Genz-112638 or placebo (water) by twice daily oral gavage (120 mg/kg/day) for 22 weeks, while remaining on the HFD. Sphingolipid levels were determined by high performance liquid chromatography – tandem mass spectrometry (see Materials and Methods). Data shown as mean ± SEM (n = 6–9 mice per group). *P<0.05, **P<0.01 Genz-112638 DIO vs. Water DIO.
