Simulations of the effects of long-term synaptic plasticity -I.

(A) Simulated intracellular changes (top) and LFP changes (bottom) in vivo obtained by changing release probability (p) alone (left) or together intrinsic excitability (IE) (right). (B) The plots show the LFP T-wave and C-wave peak amplitude changes caused by release probability, p. The three different curves represent levels of IE (low, normal and high). Note that LTP and LTD changes similar to those observed experimentally occur when both p and IE change bidirectionally around the control value. Each trace is the average of 15 simulations.