Simulation results for implementing a time-dependent adaptation of the fusion–fission rate.

(A)–(C) Reference simulation: (A) Transition rates of all processes normalized to their individual maximal values as function of time. The blue, red and green curves are on top of each other. (B) Average quality of mitochondria as function of time over all states (blue) and over active states (green). Error bars correspond to the standard deviation of the distribution and are plotted single-sided for reasons of clarity. (C) Fraction of mitochondria in the non-active state (red) and in active states (green) as function of time. (D)–(F) Random molecular damage: the same quantities as in (A)–(C) are plotted. (G)–(I) Infectious molecular damage: the same quantities as in (A)–(C) are plotted.