Simulating platelet activation.

<p>(<b>A</b>) Mean substrate conversion across all replicates for the donors shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000950#pcbi-1000950-g004" target="_blank"><b>Figure 4</b></a>. Substrate conversion traces without platelet activation are shown in solid lines and conversion traces upon activated platelets are shown in dashed lines. (<b>B</b>) Setting the initial activation state allows us to simulate platelet activation and its dynamic effect on all platelet dependent unbinding rates <i>(see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000950#s4" target="_blank">Methods</a>)</i>. The red line indicates simulations of substrate conversion without prior platelet activation . The blue dashed line indicate simulations of substrate conversion upon instantaneously fully activated platelets at <i>t = 0</i>. .</p>

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