Simulated model behavior in abnormal physiological conditions obtained by varying some parameters.

Panel A reports the Time course of model-simulated arterial pressure (mmHg), on the left, and the model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter k_xf. The continuous line describes the trend in the physiological situation (k_xf = 0.5), the dashed black line describes the trend with k_xf = 0.7 whereas the dashed gray line describes the trend with k_xf = 0.3. Panel B reports the time course of model-simulated arterial pressure (mmHg), on the left, and model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter k_h. The continuous line describes the trend in the physiological situations (k_h = 0.05), the dashed black line describes the trend with k_h = 0.07 and the dashed gray line describes the trend with k_h = 0.02. Panel C reports the time course of model-simulated arterial pressure (mmHg), on the left, and model-simulated cerebral blood flow velocity (CBFV, mL/sec), on the right, varying the parameter k_xca. The continuous line describes the trend in the physiological situations (k_xca = 0.01), the dashed black line describes the trend with k_xca = 0.06 whereas the dashed gray line describes the trend for k_xca = 0.005.