Significantly different pathways comparing glucosamine and chondroitin supplementation to placebo via gene-set enrichment analysis in Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) databases (n = 18).

<p><sup>1</sup> Among the total number of genes in the pathway, number of unique genes in our array data</p><p><sup>2</sup> Total number of corresponding antibody probes in the assay</p><p><sup>3</sup> Among the significant probes, via paired t-test comparing G&C to placebo, the number that have an effect size >0</p><p><sup>4</sup> Among the significant probes, via paired t-test comparing G&C to placebo, the number that have an effect size <0</p><p><sup>5</sup> GO = Gene Ontology; KEGG = Kyoto Encyclopedia of Genes and Genomes</p><p>*All pathways listed were statistically significant with Bonferroni correction (<i>P</i> <3.85x10<sup>-4</sup> for KEGG pathway; <i>P</i><5.18x10<sup>-5</sup> for GO pathway)</p><p>Significantly different pathways comparing glucosamine and chondroitin supplementation to placebo via gene-set enrichment analysis in Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) databases (n = 18).</p>