Significantly different pathways comparing glucosamine and chondroitin supplementation to placebo via gene-set enrichment analysis in Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) databases (n = 18).

1 Among the total number of genes in the pathway, number of unique genes in our array data

2 Total number of corresponding antibody probes in the assay

3 Among the significant probes, via paired t-test comparing G&C to placebo, the number that have an effect size >0

4 Among the significant probes, via paired t-test comparing G&C to placebo, the number that have an effect size <0

5 GO = Gene Ontology; KEGG = Kyoto Encyclopedia of Genes and Genomes

*All pathways listed were statistically significant with Bonferroni correction (P <3.85x10-4 for KEGG pathway; P<5.18x10-5 for GO pathway)

Significantly different pathways comparing glucosamine and chondroitin supplementation to placebo via gene-set enrichment analysis in Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) databases (n = 18).