Signaling time depends on the number of initiation events.

can increase or decrease as a function of depending on the value of . Here . (A) vs. CV of for varying from (red) to (green) to (blue) using the Bernoulli delay distribution in Example with . Note the transition that occurs at . (B) Equivalent to (A), but plotting CV of the signaling time instead of conditional expectation. (C) and (D) Contour plots corresponding to (A) and (B), respectively. Notice that for fixed , signaling time CV can change non-monotonically with . For instance, at , signaling time CV starts low (red), increases to (green) and then decreases thereafter. Plots were obtained through stochastic simulation with trials.