Sequence variability in LRRNT and LRRCT.

The Shannon entropy was calculated from 192 sea lamprey (Petromyzon marinus) VLRA sequences (A), 640 sea lamprey (Petromyzon marinus) VLRB sequences (B), 102 Japanese lamprey (Lethenteron japonicum) VLRC sequences (C), 98 inshore hagfish (Eptatretus burgeri) VLRB sequences (D), or 226 inshore hagfish (Eptatretus burgeri) VLRC sequences (previously reported as hagfish VLRA) (E). The molecular surfaces were calculated with the structure of lamprey VLRA.R2.1 (PDBID 3G3A) (A), lamprey VLRB.2D (PDBID 3M18) (B), lamprey VLRC from this study (C), hagfish VLRB.59 (PDBID 2O6S) (D), and hagfish VLRA.29 (VLRC.29 according to the new nomenclature) (PDBID 2O6Q) (E). Sequence variability is indicated by the color gradation from red (the most variable positions) to blue (the least variable positions) as in Figure 3. LRR1, LRRVs, LRRVe and CP are shown in gray.