Figure_3.tif (934.68 kB)
Scheme of activation of the therapeutic molecule in cells infected with HCV.
figure
posted on 2013-02-20, 21:25 authored by Xiaoyu Wen, Takayuki Abe, Hiroshi Kukihara, Shuhei Taguwa, Yoshio Mori, Hideki Tani, Nobuyuki Kato, Tetsuro Suzuki, Masashi Tatsumi, Kohji Moriishi, Yoshiharu MatsuuraThe chimeric molecules are cleaved by HCV NS3/4A protease and the released fragments inhibit propagation of HCV through induction of IFN after translocation into the nucleus (cIRF7) or disruption of the replication complex (cVAP-C), whereas the molecule is stably anchored in the ER within uninfected cells.
