Schematic representation of overall finding and hypothesis in this work.
2011-11-29T02:39:07Z (GMT) by
<p>Zebrafish was exposed to six different chemicals at varying concentrations and exposure durations. Upon exposure to these chemicals, the underneath homeostatic process as schematically illustrate in the pyramid will be initiated. The arrow beside illustrates the spread of homeostatic signals from smaller molecular scale to larger scale composing pathway networking. These chemicals will trigger conformational changes of signaling receptors and enzymes, resulting differential gene expression causing altered proteome content. If the chemicals are above certain threshold levels that a fish can cope for maintaining its normal physiological equilibrium, rewiring of molecular pathways via deregulated gene expression can take place leading to inverted profiles of hubs. The inverted functionality of hubs can be perceived as a two-component bistable switch that toggles a cell from one state to another, leading to toxicopathological states at either Scheme A (activation of hubs among Group A with suppression of hubs among Group B) or Scheme B (activation of hubs among Group B with suppression of hubs among Group A), depending on how the overall molecular rewiring drives the cell in navigating the toxicopathological landscape.</p>