S. Typhi-specific homing potential of circulating Treg.
Net S. Typhi-specific expression of A) integrin 47, (TD n = 6, No TD n = 6) B) CXCR3, (TD n = 6, No TD n = 6) C) CCR6 (TD n = 6, No TD n = 6) Values are shown as the mean +/- SEM. Scatter plots showing the net expression of D) integrin α4β7, E) CXCR3, and F) CCR6 on S. Typhi-specific Treg. Means are indicated with a black horizontal line. Time points with statistically significant differences between TD and No TD volunteers (*) or among time-points within each group (#) are identified. P-values were determined using a mixed effects regression model. TD (blue squares); No TD (red circles). Values from multiple time-points were grouped together in time segments (1–4, 5–9, 10–14, and 21–28 days post-challenge) to account for variability in the numbers of samples available from each volunteer. Some volunteers had samples from multiple time-points in a time-segment resulting in more data points than the corresponding number of volunteers.
