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S. Typhi-specific cytokine production following Treg depletion.
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posted on 2015-05-22, 02:59 authored by Monica A. McArthur, Stephanie Fresnay, Laurence S. Magder, Thomas C. Darton, Claire Jones, Claire S. Waddington, Christoph J. Blohmke, Gordon Dougan, Brian Angus, Myron M. Levine, Andrew J. Pollard, Marcelo B. SzteinPercentage of CD4+ FoxP3+ T cells following A) mock depletion or B) CD25 depletion in a representative volunteer. Production of IFN-γ and/or TNF-α by S. Typhi-specific CD8+ TEM following C) mock or D) CD25 depletion. E) Data are presented as fold increases in IFN-γ and/or TNF-α production by S. Typhi-specific total CD8+ TEM in depleted vs mock-depleted cultures, as well as by CD8+ TEM expressing, or not, integrin α4β7.
