Reversal by AOAA of upregulation of NaV1.7 and NaV1.8 expression.
(A) Western blots for NaV1.7 expression from ganglia of control (CON) and HIS rats. Actin control for each sample was given. After HIS, the relative density of NaV1.7 was increased by 214% (n = 3 rats; *p<0.05). (B) Western blots for NaV1.7 from ganglia of HIS rats treated with normal saline (NS) or AOAA. AOAA treatment significantly reduced NaV1.7 expression (n = 3 rats; *p<0.05). (C) Western blots for NaV1.8 expression from ganglia of control (CON) and HIS rats. After HIS, the relative density of NaV1.8 was increased by 247% (n = 4 rats; *p<0.05). HIS treatment enhanced NaV1.7 and NaV1.8 expression. (D) Western blots for NaV1.8 from ganglia of HIS rats treated with normal saline (NS) or AOAA. AOAA treatment significantly reduced NaV1.8 expression (n = 3 rats; *p<0.05).
