Renal Histological Assessment

<p>C57BL/6 mice, C57BL/6.<i>Apcs</i><sup>−/−</sup> mice, and C57BL/6.129(D1Mit105–223) congenic mice were sacrificed at 1 y of age to obtain age-matched autopsy specimens. Bouin's fixed kidney sections were scored blinded for glomerulonephritis<b>.</b> Glomerulonephritis was graded on a 0–3 scale (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0020243#s4" target="_blank">Materials and Methods</a> for details).</p>

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