Relevant calculated populations and maximal contact lifetimes between linker and TI loop residues.

<p>Relation of connected and broken states (population) and maximal contact lifetimes for each interaction during the whole simulation of 50 ns are listed. For determining the population, the existence of a contact was checked in 100-ps-steps. Thus, the total number of possible states is 500. For the contact definition, a cut-off sphere of 3.5 Å is used. Beyond this value, a contact is defined as broken.</p>