Figure_3.tif (4.66 MB)

Relative quantification of DOX-responder microRNAs in rat heart across all groups.

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posted on 2012-07-31, 02:35 authored by Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R. Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K. Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S. Paules, François Pognan, Frank Staedtler, Martin P. Vidgeon-Hart, Olivier Grenet, Philippe Couttet

Relative quantification of (A) miR-208b, (B) miR-215, (C) miR-216b, (D) miR-367 and (E) miR-34c in DOX, DOX + DZR, EPS groups, normalized versus vehicle treated animals. Expression levels were measured by single assay qPCR (n = 3, except #, n = 2). DOX: Doxorubicin, DZR: dexrazoxane, EPS: etoposide; numbers indicate the weekly dose of each compound in mg/kg/week. Empty spaces represent non-sampled animals. The vehicle treated is the first column of each time-point. The animals used in this experiment were distinct from the ones represented in Table 1. Error bars represent SD. T-test results are indicated by asterisks for significant DOX-treated groups vs. their own vehicle-treated, unless otherwise specified by horizontal range bars; *P<0.05, **P<0.01, ***P<0.005, NS = Non-Significant).