Regulator effects network generated from Ingenuity Pathways Analysis.
Upstream regulators are displayed in the top tier, while diseases, functions and phenotypes are displayed in the bottom tier. The dataset genes that connect the upper regulators and the lower diseases and functions are displayed in the middle tier. The causal consistency relationships are represented with orange and blue lines, while the inconsistent relationships are represented as yellow line. Note that some of the dataset genes displayed in the middle tier may have been predicted to be activated or inhibited by upstream regulators, and under such situation is colored orange or blue, respectively (for example CCND1 and E2F1 in the network).