Reduced CSF acetylcholinesterase (AChE) activity both in patients with AD and other dementias compared to healthy controls.

A) CSF AChE activity, B) CSF butyrylcholinesterase (BuChE) activity, and C) CSF AChE/BuChE ratio in the study population of patients with AD (n = 28), other dementias (n = 12), SMCI (n = 12), and healthy controls (n = 17). Values in the box plots are given as medians (horizontal lines), 25th-75th percentiles (boxes), and ranges (whiskers). Between-group differences were assessed using the Kruskal-Wallis test for multiple variables, followed by the Mann-Whitney U test for pair-wise comparisons. * P < 0.05 **P < 0.01 .