Recovery of propofol, propanidid, AZD3043, 5J in rabbits after a 20-min or 1-h or 3-h IV infusion.

(A), Duration of LORR. (B), the time to walk. Induction of hypnosis in rabbits was achieved using 2× HD₅₀ dose of test compound, and immediately after induction, infusion via the tail vein was commenced at half the HD₅₀ dosage per min. propofol (1.5 mg·kg⁻¹·min⁻¹; n = 4, 4, or 3, respectively), propanidid (2.5 mg·kg⁻¹·min⁻¹; n = 5, 4, or 5, respectively), AZD3043 (2.4 mg·kg⁻¹·min⁻¹; n = 5, 4, or 5, respectively), 5j (3.0 mg·kg⁻¹·min⁻¹; n = 5, 4, or 5, respectively) in rabbits. *P<0.05 compared with propanidid, ^#P<0.05 versus AZD3043, a one-way ANOVA with Dunnett's post hoc test.