Protective effect of Tamiflu® in 11-week-old, A/swine/Potsdam/15/1981 (H1N1/1981) virus challenged pigs (n = 10) in comparison to RESPIPORC® FLU3-vaccinated (n = 10) and untreated animals (n = 12).

Dyspnoea (A), rectal temperatures (B), virus titres in nasal swabs, n = 10 animals/group/day until day 2 p.i. and n = 5 from day 3 p.i. on, exception: n = 12 untreated animals at day 0 to 2 p.i. and n = 7 untreated animals/day at 3 to 7 p.i. (C), and mean of histopathological scores with standard deviations and representative photographs of formalin fixed, HE stained lungs (D) are shown (am morning; pm afternoon; p statistical probability: *p<0.05, **p<0.01, ***p<0.001, a vaccinated group versus control group, b Tamiflu®-treated group versus control group, c vaccinated group versus Tamiflu®-treated group, Mann-Whitney-U-test). The detection limit of virus titre determination is shown as dotted line (C).