Prediction of SH2-mediated protein-protein interactions using FoldX and experimental data from peptide libraries.

The orange line corresponds to random prediction, and the grey line to prediction for all nine domains in Table 1. (A) Comparison of predictions from experimental consensus sequences allowing zero (square) and one mismatch (circle) with the consensus sequence with FoldX predictions for the eight domains in Table 1 for which a consensus sequence is available (blue line). (B) Comparison of predictions from Scansite scoring matrices for the Nck1, p85, Src, Lck, and Grb2 SH2 domains (green line) with FoldX predictions for the same domains (blue line).