Prediction error for all methods.

Distribution of the normalized prediction error for each method across multiple conditions for the different datasets. Each box plot represents the distribution of the prediction error for all conditions in one dataset. Two scenarios are evaluated: prediction of the complete metabolic phenotype (growth, secretion and intracellular fluxes) from measured uptake rates (a–c); and prediction of the intracellular fluxes from the measured physiology (growth, uptake and secretion rates) (d–f).