Post-exposure anti-H3+B5 hmAb protection in rabbits.

(A) VACV neutralization in vitro. (B–F) Post-exposure protection of rabbits against rabbitpox. 32 New Zealand White (NZW) rabbits were challenged with 1x105 PFU of RPXV intranasally. Group 1 (n = 10) received no treatment, Group 2 (n = 6) and group 4 (n = 10) received two I.V. injections of antibody cocktail at 9 mg/kg and 1.25 mg/kg respectively, one hour and 72 hours post-challenge. Group 3 (n = 6) received a single I.V. injection of antibody cocktail at 9 mg/kg 2 days post-challenge. (B) Body Weights. (C) Percent change from initial body temperature. (D) Percent change from initial respiration rate. (E) Clinical scores. (F) Percent survival.