Positive linear (a) or quadratic (b) relationship observed between age and MMSE in MRI (blue) and FDG-PET (red) in AD patients after removing the variance explained by heathy aging.

<p>Only clusters are shown exceeding a significance threshold of p = 0.001 uncorrected on voxel level and p = 0.05 FWE-corrected on cluster level. AD Alzheimer's disease, FDG-PET [18F]fluorodeoxyglucose positron emission tomography, MRI structural magnetic resonance imaging.</p>