Platelet PI3Kγ contributes to activated platelets induced intima-media thickening after partial ligation.
2015-06-08T02:47:16Z (GMT) by
<p>(A) Representative Verhoeff’s elastic stained cross sections (level 3) of left common carotid arteries from WT mice treated with PBS (Vehicle), WT platelets (WT plts), or PI3Kγ<sup>-/-</sup> platelets (PI3Kγ<sup>-/-</sup> plts) (n = 5 per group) at 21 d after partial ligation. (B) Schematic diagram of partial ligation and tissue microtomy. Intima+ media areas (C) were measured at seven section levels (200μm intervals), and their mean values were determined. Data are expressed as mean ± SEM. * <i>P</i><0.05 versus vehicle, # <i>P</i><0.05 versus WT platelet-infused mouse. Light microscope magnification is 10×.</p>