Figure_7.tif (1.2 MB)
Phenotype of polarized M-CSF and GM-CSF MΦ.
figure
posted on 2013-10-21, 03:22 authored by Nicolai A. Kittan, Ronald M. Allen, Abhay Dhaliwal, Karen A. Cavassani, Matthew Schaller, Katherine A. Gallagher, William F. Carson IV, Sumanta Mukherjee, Jolanta Grembecka, Tomasz Cierpicki, Gabor Jarai, John Westwick, Steven L. Kunkel, Cory M. HogaboamMΦ that were differentiated in M-CSF (A) and GM-CSF (B) were further polarized using IFN-γ or IL-4+IL-13. Characteristic features of M-CSF vs. GM-CSF MΦ are depicted in the upper part. Additional changes found in this study, induced by the polarization process are shown in the lower section with characteristic genes, surface markers and epigenetic changes for M-CSF and GM-CSF M1and M2 MΦ.
