posted on 2013-10-21, 03:22authored byNicolai A. Kittan, Ronald M. Allen, Abhay Dhaliwal, Karen A. Cavassani, Matthew Schaller, Katherine A. Gallagher, William F. Carson IV, Sumanta Mukherjee, Jolanta Grembecka, Tomasz Cierpicki, Gabor Jarai, John Westwick, Steven L. Kunkel, Cory M. Hogaboam
MΦ that were differentiated in M-CSF (A) and GM-CSF (B) were further polarized using IFN-γ or IL-4+IL-13. Characteristic features of M-CSF vs. GM-CSF MΦ are depicted in the upper part. Additional changes found in this study, induced by the polarization process are shown in the lower section with characteristic genes, surface markers and epigenetic changes for M-CSF and GM-CSF M1and M2 MΦ.