Phenazine synthesis by <i>P. aeruginosa</i> is essential for killing <i>C. elegans</i>.

<p>(A) Phenazine synthesis pathway of <i>P. aeruginosa</i>. (B) Killing of wild-type <i>P. aeruginosa</i> PA14 and Δ<i>phz</i> mutant and partial complementation of Δ<i>phz</i> killing with plasmids containing either the <i>phzA1-G1</i> or <i>phzA2-G2</i> operon. (C) Complementation of killing in the Δ<i>phz</i> mutant by addition of synthetic phenazine-1-carboxylic acid (100 µg/mL) to the agar medium prior to plating and growth of the bacteria.</p>