Perievent Time Histogram and z-scores of multiunit activity in the hippocampus during DS.

MUA activity and z score of A) CA1 pyramidal cell layer and B) dentate granule cell layer in control animals. MUA activity and z score of C) CA1 pyramidal cell layer and D) dentate granule cell layer in pilocarpine-treated animals. The peak amplitude of DS was locked to time zero, depicted by the vertical dashed red line, in all perievent time histograms. Horizontal dashed red lines in z score plots indicate a z score of 3. No significant increase in MUA was seen in the CA1 pyramidal cell layer in either control or pilocarpine-treated animals. However, in both groups a significant increase in MUA, demonstrated by z-scores ≥3, was observed 5ms before and after DS.