Patterns of Oncogene Activation and TSG Inactivation.

All 117 tumours are sorted by the presence (1) or absence (0) of specific aberrations in Notch1, Ikzf1, Pten, Trp53 and Bcl11b, with (-) denoting an unclear result. Patterns of activation/inactivation are highlighted by letter codes as shown in the key, for Notch1 (A-E), Ikzf1 (F-H) and Pten (I-K). Almost complete LOH at the Bcl11b locus can be observed, along with high frequency of Notch1 aberrations. Pten aberrations, and particularly homozygous Pten mutations, are more frequently associated with tumours not carrying the combined 5′ Deletion and PEST mutation in Notch1.