Pathways influenced by the validated targeted genes.

Targeted system biology analysis of the biological process and molecular function of the 4 validated genes (Superoxide dismutase 3, extracellular (EC-SOD), Glutathione S-transferase, alpha 2(Yc2) (GST-Yc2), Flavin containing monooxygenase 2 (FMO2), Insulin-like growth factor binding protein (IGFBP-1). Similar to the identified altered pathways, these 4 proteins are shown to be related to the identified molecular pathways (apoptosis, oxidative stress and inflammation).