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Paralog APL1C limits development of rodent malaria species in A. gambiae.
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posted on 2009-09-11, 01:23 authored by Christian Mitri, Jean-Claude Jacques, Isabelle Thiery, Michelle M. Riehle, Jiannong Xu, Emmanuel Bischoff, Isabelle Morlais, Sandrine E. Nsango, Kenneth D. Vernick, Catherine BourgouinA) Silencing of APL1C but not APL1A or APL1B permits significantly higher oocyst intensity in mosquitoes fed on mice infected with P. berghei. B) Silencing of APL1C also permits significantly higher P. berghei infection prevalence. Increases in both parasite intensity and infection prevalence were observed for another rodent malaria parasite, P. yoelii, following silencing of APL1C but not APL1A or APL1B (see Results).
