Table_1.xls (13.5 kB)

Overview of quantitative trait loci investigated in this study.

dataset

posted on 2014-01-30, 02:47 authored by Susan K. Service, Tanya M. Teslovich, Christian Fuchsberger, Vasily Ramensky, Pranav Yajnik, Daniel C. Koboldt, David E. Larson, Qunyuan Zhang, Ling Lin, Ryan Welch, Li Ding, Michael D. McLellan, Michele O'Laughlin, Catrina Fronick, Lucinda L. Fulton, Vincent Magrini, Amy Swift, Paul Elliott, Marjo-Riitta Jarvelin, Marika Kaakinen, Mark I. McCarthy, Leena Peltonen, Anneli Pouta, Lori L. Bonnycastle, Francis S. Collins, Narisu Narisu, Heather M. Stringham, Jaakko Tuomilehto, Samuli Ripatti, Robert S. Fulton, Chiara Sabatti, Richard K. Wilson, Michael Boehnke, Nelson B. Freimer

The loci are named according to the first gene in the region of interest, starting at the 5′ end of the region.

ROI = region of interest. Number of kb sequenced for the locus.

Total Genes is the number of genes in the locus; Targeted Genes is the number of genes investigated in this study.

Please see Table S3 for a complete listing of all variant sites, along with their MAF and annotation.

Phenotype abbreviations: TC = total cholesterol, LDL-C = low density lipoprotein cholesterol, HDL-C = high density lipoprotein cholesterol, TG = triglycerides, FG = Fasting Glucose, FI = Fasting Insulin. Previous association evidence for lipid traits is from Kathiresan et al. 2008, Willer et al. 2008 and Teslovich et al. 2010; for glucose Dupuis et al. 2010, and for insulin Sabatti et al. 2009. The “array SNP” is the GWAS array-genotyped SNP (not sequence variant) with the smallest p-value to indicated traits in this study and is not necessarily the same SNP highlighted in previous studies.

Array SNP MAF and p-values are taken from the current study.