## Outline of the algorithm to compute Collagen Alignment Index (CAI).

figure

posted on 20.02.2013 by Cemal Cagatay Bilgin, Amanda W. Lund, Ali Can, George E. Plopper, Bülent Yener#### figure

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After segmenting the nuclei, cell-graph are built capturing the spatial distribution. Voronoi diagrams are built and the gradient vectors in each Voronoi compartment are calculated. A distribution of the angles between the cell-graph edges and the gradient vectors is calculated to find the CAI metric.