Osx-cre; Raptorf/fmice exhibited reduced trabecular bone mass.
(A-B) Representative X-ray images of hind limbs of 6 week-old Osx-Cre (Ctrl) (A) or Osx-Cre; Raptorf/f(RapCKO) mice. (B). (C-D) μCT three-dimensional reconstruction of metaphyseal trabecular bone of the tibia from 6 week-old Osx-Cre (Ctrl) (C) or Osx-Cre; Raptorf/f (RapCKO) littermate mice(D). (E-H) μCT quantification of proximal metaphyseal trabecular bone parameters. BV: bone volume; TV: total volume; Tb. N*: trabecular number; Tb. Th*: trabecular thickness; Tb. Sp*: trabecular spacing. Quantification was performed on 100 of 16 μm slices immediately below the growth plate. Ctrl: n = 5; RapCKO: n = 4; *:P<0.05.