Normal growth but increased glycogen storage in liver and skeletal muscle of 129S6/SvEv Cthrc1 null mice.

(A) Differences in litter size were not significantly different (n.s.). (B) Growth curves for females and (C) males were similar (n = 5–33 mice per time point). (D, E) Total body fat expressed as a percentage of body weight was similar in 8 week old female mice among mutants and wild type mice. (F) Blood triglyceride levels in 3–4 month old male and female mice were similar. (G) Glycogen storage in skeletal muscle and (H) liver is significantly increased in Cthrc1 null mice on the 129S6/SvEv background (males and females, 3–5 months of age). (I) Glucose handling is normal in Cthrc1 null mice (n = 8 per group, mixed gender, 3–4 months old). (J) Reduced insulin sensitivity was observed in Cthrc1 null mice (n = 8 per group, mixed gender, 3–4 months old).