Network profiles and interactions between targets of drug combinations.

A) Radar plots showing representative network property profiles of targets of drug combination. MEK and BRAF network property profiles are more similar to one another than the network profiles of CDKs and HMGCR. This may be related to the long-term effectiveness of the combinations of drugs targeting these proteins. B) Interactions between proteins targeted by drug combination showing high level of connectivity between targets such as EGFR, BRAF and MEK. The dotted edge indicates that no direct interaction takes place between HMGCR and the other proteins in the network.