Neonatal S. pneumoniae infection enhances ovalbumin-induced airway hyperresponsiveness.

Whole-body plethysmography in uninfected, allergic (OVA), neonatal infected, allergic (Neo/OVA), neonatal infected, non-allergic (Neo), and uninfected, non-allergic (control) mice was conducted 24 h following challenge with methacholine. Data are reported as mean ± standard error from three separate experiments (n = 6–8 mice/group); *P < 0.05, **P < 0.01, ***P < 0.001 vs. control; ^#P < 0.05, ^###P < 0.001 vs. OVA.