Figure_10.tif (998.95 kB)
NF-kB and TXNIP induced NLRP3 inflammasome activation.
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posted on 2014-08-19, 03:12 authored by Beibei Luo, Bo Li, Wenke Wang, Xiangjuan Liu, Yanfei Xia, Cheng Zhang, Mingxiang Zhang, Yun Zhang, Fengshuang AnRelative mRNA expression of NF-kB (A) and protein levels of NLRP3, pro-caspase-1, activated caspase-1, pro-IL-1β and mature IL-1β (B-G) in H9c2 cardiomyocytes with treatment. Relative mRNA expression of TXNIP (H) and protein levels of TXNIP, NLRP3, pro-caspase-1, activated caspase-1, pro-IL-1β and mature IL-1β (I-O) in H9c2 cardiomyocytes. Data were presented as means±SEM, from 3 independent experiments. *p<0.05, **p<0.01 vs. Ctrl; §§p<0.01 vs. HG+vehicle.
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H 9c cellstunelNLRP 3 inflammasome activationNLRP 3 inflammasome activation.ResultsDiabetic ratsrostype 2 DCMNLRP 3 Gene Silencing Ameliorates Diabetic CardiomyopathytxnipnfascNLRP 3 inflammasomeNLRP 3 geneH 9c cardiomyocytesmechanism involved.MethodsType 2Caspase Recruitment DomainNLRP 3ilCell death
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