Myc increases the severity of spontaneous DSB-mediated mutations.

<p>Control larvae are labeled as “+” and are the genotype hs-FLP/+ (or Y); <i>lacZ</i> #2/+; actin>CD2>Gal4, UAS-GFP/+ and Myc overexpressing larvae are labeled “Myc” and are the genotype hs-FLP/+ (or Y); <i>lacZ</i> #2/+; actin>CD2>Gal4, UAS-GFP/UAS-Myc. N indicates the number of breakpoint events counted. “Indels” are insertion and deletion events within the <i>lacZ</i> gene and translocations involve sequence within the <i>lacZ</i> reporter gene from another chromosome. Small indels are defined as less then 10 kb and large indels are 10 kb or greater.</p>