Figure_2.tif (4 MB)
Molecular interactions of C34 with the TLR4-MD2 complex.
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posted on 2013-06-12, 02:13 authored by Matthew D. Neal, Hongpeng Jia, Benjamin Eyer, Misty Good, Christopher J. Guerriero, Chhinder P. Sodhi, Amin Afrazi, Thomas Prindle Jr, Congrong Ma, Maria Branca, John Ozolek, Jeffrey L. Brodsky, Peter Wipf, David J. HackamX-ray structure of E5564 (A and C) and docking model of C34 (B and D) with the TLR4-MD2 complex, illustrating the interaction of E5563 and C34, respectively, with the hydrophobic groove of MD-2. Panel E displays the amino acid residues on hMD2 within a 5 Å contact radius of C34. See Results for additional details.
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immunologyImmune responseImmune systemimmunomodulationmicrobiologySynthetic Biologychemical biologycomputational chemistrymedicinal chemistryCritical care and emergency medicineGastrointestinal critical carePediatric critical caresepsisGastroenterology and hepatologyInflammatory bowel diseasePediatric gastroenterologySmall intestineinteractionsc34tlr4-md2
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