Fig 8.tif (1.35 MB)
Model depicting IL-13 inhibition of LPS-induced BPIFA1 expression in nasal epithelial cells.
dataset
posted on 2015-12-08, 07:05 authored by Yung-An Tsou, Chia-Der Lin, Hui-Chen Chen, Hui-Ying Hsu, Lii-Tzu Wu, Chuan Chiang-Ni, Chih-Jung Chen, Tsu-Fang Wu, Min-Chuan Kao, Yu-An Chen, Ming-Te Peng, Ming-Hsui Tsai, Chuan-Mu Chen, Chih-Ho Lai(A) The bacterial cell wall component LPS upregulates BPIFA1 expression through the JNK/c-Jun signaling pathway, followed by AP-1 activation. (B) IL-13, a TH2-skewed cytokine, suppresses LPS-induced BPIFA1 expression in nasal epithelial cells from patients with eosinophilic CRSwNP.
