Metabolic pathways possibly responsible for the differences observed in NOD and B6 mice.

Metabolite concentrations at weeks 0, 3, 4, 5 and 15 are indicated with colors. Red indicates significantly increased in NOD, blue indicates significantly increased in B6 and white indicates no significant difference. Enzymes involved in metabolism are also show in the plot. Red text indicates that the gene is in Idd region and bold, italic text indicates SNPs differentiating NOD and B6 mice. A. Metabolism around the TCA cycle with glutamic acid and glutamine. B. Metabolism of nucleic acid compounds.