MD simulations of KIT cytoplasmic region in the auto-inhibited inactive form.

<p>The RMS deviations (in Å) were calculated from MD simulations of full-length CR for wild-type KIT, WT<sup>547-935</sup> (in blue), and D816V mutant, MU<sup>547-935</sup> (in red), on the backbone atoms of (<b>a</b>) the whole CR, (<b>b</b>) N-lobe, (<b>c</b>) C-lobe, (<b>d</b>) A-loop and (<b>e</b>) JMR. The 50-ns simulations <b>1</b> and <b>2</b> of the wild-type (mutant, respectively) are shown by plain and dashed lines. The dashed grey vertical line drawn at 2 ns indicates the relaxation time.</p>